Protein chemical synthesis in medicinal chemistry
Résumé
Although the majority of proteins used for biomedical research are produced using living systems such as bacteria, biological means for producing proteins can be advantageously complemented by protein semisynthesis or total chemical synthesis. The latter approach is particularly useful when the proteins to be produced are toxic for the expression system or show unusual features that cannot be easily programmed in living organisms. The aim of this perspective article is to provide a wide overview of the use of protein chemical synthesis in medicinal chemistry with a special focus on the production of side-chain or backbone-modified proteins.
Domaines
Chimie thérapeutiqueOrigine | Fichiers produits par l'(les) auteur(s) |
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