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Article Dans Une Revue Nature Nanotechnology Année : 2020

Optomechanical detection of vibration modes of a single bacterium

Résumé

Low-frequency vibration modes of biological particles such as proteins, viruses and bacteria involve coherent collective vibrations at frequencies in the terahertz and gigahertz domains. These vibration modes carry information on their structure and mechanical properties, which are good indicators of their biological state. In this work, we harness a particular regime in the physics of coupled mechanical resonators to directly measure the mechanical resonances of single bacterium. We deposit the bacterium on the surface of an ultra-high frequency optomechanical disk resonator in ambient conditions. The vibration modes of the disk and bacterium hybridize when their associated frequencies are similar. We develop a general theoretical framework to describe this coupling, which allows us to retrieve the eigenfrequencies and mechanical loss of the bacterium vibration modes (Q factor). Finally, we analyse the effect of hydration on the vibrational properties of a single bacterium. This work demonstrates that ultrahigh frequency optomechanical resonators can be used for vibrational spectrometry with the unique capability to obtain information on single biological entities.
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Dates et versions

hal-03052514 , version 1 (10-12-2020)

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Eduardo Gil-Santos, Jose J Ruz, Oscar Malvar, Ivan Favero, Aristide Lemaitre, et al.. Optomechanical detection of vibration modes of a single bacterium. Nature Nanotechnology, 2020, 15 (6), pp.469-474. ⟨10.1038/s41565-020-0672-y⟩. ⟨hal-03052514⟩
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