Ultrabright Silica-Coated Organic Nanocrystals for Two-Photon In Vivo Imaging - Archive ouverte HAL
Article Dans Une Revue ACS Applied Nano Materials Année : 2020

Ultrabright Silica-Coated Organic Nanocrystals for Two-Photon In Vivo Imaging

Shridevi Shenoi Perdoor
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Fabien Dubois
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Aude Barbara
Olivier Pascual
Guillaume Micouin
Akos Banyasz
Yann Bretonnière
Chantal Andraud
Alain Ibanez
X. Cattoen

Résumé

Herein, we demonstrate the potential of ultrabright fluorescent silica-coated organic nanocrystals for two-photon in vivo imaging. These unique nanoparticles (NPs) containing a crystalline core of small push-pull dipolar dye are specifically designed to exhibit two-photon absorption for 2 fluorescence imaging. The NPs can be easily functionalized using click chemistry in pure water, with preservation of the organic core. A novel small-volume DLS technique was used to evaluate the effect of PEGylation on the colloidal stability of the NPs in complex media containing salts and proteins, mimicking the composition of blood serum. The potential of these bright red-emitting NPs for two-photon fluorescence imaging is demonstrated both in vitro and in vivo.
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Dates et versions

hal-03046950 , version 1 (08-12-2020)

Identifiants

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Shridevi Shenoi Perdoor, Fabien Dubois, Aude Barbara, Christophe Nguyen, Lamiaa Mohamed Ahmed Ali, et al.. Ultrabright Silica-Coated Organic Nanocrystals for Two-Photon In Vivo Imaging. ACS Applied Nano Materials, 2020, 3 (12), pp.11933-11944. ⟨10.1021/acsanm.0c02499⟩. ⟨hal-03046950⟩
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