Silver(I) Oxide‐/DBU‐Promoted Synthesis of Dihydrofuran Units through Allenyl Silver Formation
Résumé
A formal [3+2] cyclization mediated by silver(I) oxide and DBU is described herein. Through a broad variety of carbonyl compounds, this system can promote cyclization reactions with high yield (up to 85%) and diastereoselectivity (up to 95:5) for a straightforward access to complex and congested dihydrofuran derivatives in one step using smooth conditions. Based on DFT studies, the proposed mechanism would involve an allenyl silver intermediate.
Domaines
Chimie
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