Update on Müller glia regenerative potential for retinal repair
Résumé
Retinal regeneration efficiency from Mü ller glia varies tremendously among vertebrate species, being extremely limited in mammals. Efforts towards the identification of molecular mechanisms underlying Mü ller cell proliferative and neurogenic potential should help finding strategies to awake them and ensure regeneration in mammals. We provide here an update on the most recent and original progresses made in the field. These include remarkable discoveries regarding (i) unprecedented cross-species comparison of Mü ller cell transcriptome using single-cell technologies, (ii) the identification of new strategies to promote both the proliferative and the neurogenic potential of mammalian Mü ller cells, (iii) the role of the epigenome in regulating Mü ller glia plasticity, (iv) miRNA-based regulatory mechanisms of Mü ller cell response to injury, and (v) the influence of inflammatory signals on the regenerative process.
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers produits par l'(les) auteur(s)