Topology optimization for maximizing the fracture resistance of particle-matrix composites is investigated. The methodology developed in our previous works, combining evolutionary topology optimization and phase field method to fracture embedding interfacial damage, is applied and extended to periodic composites and multiple objectives. On one hand, we constrain the periodicity of unit cells geometry and conduct their topology optimization for one given load prescribed over the whole structure. On the other hand, we consider a single unit cell whose topology is optimized with respect to the fracture energy criterion when subjected to multiple loads. Size effects are investigated. We show that significant enhancement of the fracture resistance can be achieved for the studied composite structures by the present method. In addition, a first attempt to fracture resistance enhancement of a unit cell associated with a material is investigated for multiple loads, exhibiting a complex optimized microstructure.