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Article Dans Une Revue FEBS Letters Année : 1999

Inhibition of Bcl-2-dependent cell survival by a caspase inhibitor: a possible new pathway for Bcl-2 to regulate cell death

Résumé

The REtsAF cell line expresses a temperaturesensitive mutant of the SV40 large tumor antigen. At restrictive temperature (39.5³C), the cells undergo p53-mediated apoptosis, which can be inhibited by Bcl-2. Here, we show that Z-VADfmk, a caspase inhibitor, can suppress the Bcl-2-dependent cell survival at 39.5³C. This result suggests that a caspase-like activity can act as an inhibitor of apoptosis in this model, downstream of Bcl-2. Our results also suggest that this activity may be up-regulated by Bcl-2 and may be responsible for cleavage of the tumor suppressor Rb protein.

Dates et versions

hal-03036379 , version 1 (21-12-2020)

Identifiants

Citer

V Rincheval, F Renaud, C Lemaire, Bernard Mignotte, Jean-Luc Vayssiere. Inhibition of Bcl-2-dependent cell survival by a caspase inhibitor: a possible new pathway for Bcl-2 to regulate cell death. FEBS Letters, 1999, 460 (2), pp.203-206. ⟨10.1016/s0014-5793(99)01345-9⟩. ⟨hal-03036379⟩

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