Article Dans Une Revue Physical Chemistry Chemical Physics Année : 2020

A machine learning study of the two states model for lipid bilayer phase transitions

Vivien Walter
Olivier Benzerara
Carlos M. Marques
Fabrice Thalmann

Résumé

We have adapted a set of classification algorithms, also known as Machine Learning, to the identification of fluid and gel domains close to the main transition of dipalmitoyl-phosphatidylcholine (DPPC) bilayers. Using atomistic molecular dynamics conformations in the low and high temperature phases as learning sets, the algorithm was trained to categorize individual lipid configurations as fluid or gel, in relation with the usual two-states phenomenological description of the lipid melting transition. We demonstrate that our machine can learn and sort lipids according to their most likely state without prior assumption regarding the nature of the order parameter of the transition. Results from our machine learning approach provides strong support in favor of a two-states model approach of membrane fluidity.

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hal-03101032 , version 1 (06-01-2021)

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Vivien Walter, Céline Ruscher, Olivier Benzerara, Carlos M. Marques, Fabrice Thalmann. A machine learning study of the two states model for lipid bilayer phase transitions. Physical Chemistry Chemical Physics, 2020, 22 (34), pp.19147-19154. ⟨10.1039/D0CP02058C⟩. ⟨hal-03101032⟩
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