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Article Dans Une Revue Cerebral Cortex Année : 2020

Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation

Julia von Wittgenstein
  • Fonction : Auteur
Fang Zheng
  • Fonction : Auteur
Marie-Theres Wittmann
  • Fonction : Auteur
Elli-Anna Balta
  • Fonction : Auteur
Fulvia Ferrazzi
Iris Schäffner
  • Fonction : Auteur
Benjamin Häberle
  • Fonction : Auteur
Maria Valero-Aracama
  • Fonction : Auteur
Carlos Miranda
  • Fonction : Auteur
Brian Kaspar
  • Fonction : Auteur
Arif Ekici
  • Fonction : Auteur
André Reis
  • Fonction : Auteur
Djoher Nora Abrous
Christian Alzheimer
  • Fonction : Auteur
D Chichung Lie
  • Fonction : Auteur

Résumé

Neuronal activity initiates transcriptional programs that shape long-term changes in plasticity. Although neuron subtypes differ in their plasticity response, most activity-dependent transcription factors (TFs) are broadly expressed across neuron subtypes and brain regions. Thus, how region-and neuronal subtype-specific plasticity are established on the transcriptional level remains poorly understood. We report that in young adult (i.e., 6-8 weeks old) mice, the developmental TF SOX11 is induced in neurons within 6 h either by electroconvulsive stimulation or by exploration of a novel environment. Strikingly, SOX11 induction was restricted to the dentate gyrus (DG) of the hippocampus. In the novel environment paradigm, SOX11 was observed in a subset of c-FOS expressing neurons (ca. 15%); whereas around 75% of SOX11+ DG granule neurons were c-FOS+, indicating that SOX11 was induced in an activity-dependent fashion in a subset of neurons. Environmental enrichment or virus-mediated overexpression of SOX11 enhanced the excitability of DG granule cells and downregulated the expression of different potassium channel subunits, whereas conditional Sox11/4 knockout mice presented the opposite phenotype. We propose that Sox11 is regulated in an activity-dependent fashion, which is specific to the DG, and speculate that activity-dependent Sox11 expression may participate in the modulation of DG neuron plasticity.
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Dates et versions

hal-03028758 , version 1 (14-12-2020)

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Citer

Julia von Wittgenstein, Fang Zheng, Marie-Theres Wittmann, Elli-Anna Balta, Fulvia Ferrazzi, et al.. Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation. Cerebral Cortex, 2020, 30 (6), pp.3731-3743. ⟨10.1093/cercor/bhz338⟩. ⟨hal-03028758⟩

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