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Article Dans Une Revue Pesticide Biochemistry and Physiology Année : 2020

Synergic effect of a quinuclidine benzamide complexed with borane, the LMA10233, in combination with seven pesticides

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Some quinuclidine benzamide compounds have been found to modulate nicotinic acetylcholine receptors in both mammals and insects. In particular, the quaternarization of 3-amino quinuclidine benzamide derivatives with dichloromethane gave charged N-chloromethylated quinuclidine compounds, disclosing an antagonist profile on homomeric alpha 7 nAChRs. Here, we synthesized and studied the toxicological effect of LMA10233, a quinuclidine-borane complex analogue, the LMA10233, on the pea aphid Acyrthosiphon pisum and found that LMA10233 only exhibit proper toxicity on A. pisum larvae when applied in concentrations of over 10 mu g/ml. We assessed the ability of LMA10233 to enhance the toxicity of different insecticides. When a sublethal concentration of LMA10233 was combined with the LC10 of each compound, we found a strong increase in toxicity at 24 h and 48 h of exposure for clothianidin, fipronil and chlorpyrifos, and only at 24 h for imidacloprid, acetamiprid and deltamethrin. However, when the pesticide was used at the LC50, only acetamiprid showed a synergistic effect with LMA10233. When the concentration of LMA10233 was decreased, we found that up to 80-90% of mortality was obtained due to the synergism between acetamiprid and LMA10233. No similar effect was observed with other insecticides. We conclude that such quinuclidine-borane complex compounds could increase the toxic effect of insecticides at low concentrations.

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Emiliane Taillebois, Alison Cartereau, Jérôme Graton, Jean-Yves Le Questel, Jacques Lebreton, et al.. Synergic effect of a quinuclidine benzamide complexed with borane, the LMA10233, in combination with seven pesticides. Pesticide Biochemistry and Physiology, 2020, 168, pp.104633. ⟨10.1016/j.pestbp.2020.104633⟩. ⟨hal-03027878⟩
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