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Article Dans Une Revue JCI Insight Année : 2019

Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis

Jasmohan S Bajaj
Nita Salzman
Hajime Takei
Andrew Fagan
Melanie B White
Hiroshi Nittono
  • Fonction : Auteur
I. Jane Jane Cox
Robert Andrew Atkinson
Masoumeh Sikaroodi
Patrick M Gillevet
R. Andrew Atkinson

Résumé

Hepatic encephalopathy (HE) is associated with poor outcomes. A prior randomized, pilot trial demonstrated safety after oral capsular fecal microbial transplant (FMT) in HE, with favorable changes in microbial composition and cognition. However, microbial functional changes are unclear. The aim of this study was to determine the effect of FMT on the gutbrain axis compared with placebo, using microbial function based on bile acids (BAs), inflammation (serum IL-6, LPS-binding protein [LBP]), and their association with EncephalApp.
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hal-03027470 , version 1 (23-11-2023)

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Jasmohan S Bajaj, Nita Salzman, Chathur Acharya, Hajime Takei, Genta Kakiyama, et al.. Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis. JCI Insight, 2019, 4 (24), ⟨10.1172/jci.insight.133410⟩. ⟨hal-03027470⟩
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