Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis
Résumé
Hepatic encephalopathy (HE) is associated with poor outcomes. A prior randomized, pilot trial demonstrated safety after oral capsular fecal microbial transplant (FMT) in HE, with favorable changes in microbial composition and cognition. However, microbial functional changes are unclear. The aim of this study was to determine the effect of FMT on the gutbrain axis compared with placebo, using microbial function based on bile acids (BAs), inflammation (serum IL-6, LPS-binding protein [LBP]), and their association with EncephalApp.
Domaines
Hépatologie et Gastroentérologie
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Licence : Copyright (Tous droits réservés)