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Article Dans Une Revue Frontiers in Cell and Developmental Biology Année : 2020

Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans

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Caenorhabditis elegans nematodes produce and maintain imprints of attractive chemosensory cues to which they are exposed early in life. Early odor-exposure increases adult chemo-attraction to the same cues. Imprinting is transiently or stably inherited, depending on the number of exposed generations. We show here that the Alanine tRNA (UGC) plays a central role in regulating C. elegans chemo-attraction. Naive worms fed on tRNA$^{Ala}$ (UGC) purified from odor-experienced worms, acquire odor-specific imprints. Chemo-attractive responses require the tRNA-modifying Elongator complex sub-units 1 (elpc-1) and 3 (elpc-3) genes. elpc-3 deletions impair chemo-attraction, which is fully restored by wild-type tRNA$^{Ala}$ (UGC) feeding. A stably inherited decrease of odor-specific responses ensues from early odor-exposition of elpc-1 deletion mutants. tRNA$^{Ala}$ (UGC) may adopt various chemical forms to mediate the cross-talk between innately-programmed and environment-directed chemo-attractive behavior
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hal-03027006 , version 1 (29-08-2024)

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Diana Andrea Fernandes de Abreu, Thalia Salinas-Giegé, Laurence Drouard, Jean-Jacques Remy. Alanine tRNAs Translate Environment Into Behavior in Caenorhabditis elegans. Frontiers in Cell and Developmental Biology, 2020, 8, pp.571359. ⟨10.3389/fcell.2020.571359⟩. ⟨hal-03027006⟩
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