Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now? - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Essays in Biochemistry Année : 2020

Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?

Résumé

Polyunsaturated fatty acids (PUFAs) are essential components in eukaryotic cell membrane. They take part in the regulation of cell signalling pathways and act as precursors in inflammatory metabolism. Beside these, PUFAs auto-oxidize through free radical initiated mechanism and release key products that have various physiological functions. These products surfaced in the early nineties and were classified as prostaglandin isomers or isoprostanes, neuroprostanes and phytoprostanes. Although these molecules are considered robust biomarkers of oxidative damage in diseases, they also contain biological activities in humans. Conceptual progress in the last 3 years has added more understanding about the importance of these molecules in different fields. In this chapter, a brief overview of the past 30 years and the recent scope of these molecules, including their biological activities, biosynthetic pathways and analytical approaches are discussed.

Domaines

Chimie
Fichier principal
Vignette du fichier
Ahmed et al Ess Biochem 2020, final_HAL.pdf (1.33 Mo) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03026190 , version 1 (02-06-2021)

Identifiants

Citer

Omar Ahmed, Jean-Marie Galano, Tereza Pavlickova, Johanna Revol-Cavalier, Claire Vigor, et al.. Moving forward with isoprostanes, neuroprostanes and phytoprostanes: where are we now?. Essays in Biochemistry, 2020, 64 (3), pp.463-484. ⟨10.1042/EBC20190096⟩. ⟨hal-03026190⟩
37 Consultations
319 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More