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Article Dans Une Revue Biology of the Cell Année : 2000

Ca2+ oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs

Victoria L Nixon
  • Fonction : Auteur
Keith T Jones

Résumé

At fertilisation of mammalian and ascidian eggs the sperm induces a series of Ca 2+ oscillations. These Ca 2+ oscillations are triggered by a sperm-borne Ca 2+-releasing factor whose identity is still unresolved. In both mammals and ascidians Ca 2+ oscillations in eggs are associated with the period leading up to exit from meiosis and entry into the first embryonic cell cycle. Thus, in mammals Ca 2+ oscillations continue for several hours but are complete by within 30 min in the ascidian. In mammals and ascidians Ca 2+ oscillations stop at around the time when pronuclei form in the 1-cell embryo. There is evidence to show that cell cycle factors are important in regulating the fertilisation Ca 2+ signal. If the formation of pronuclei is blocked either in mammals (by spindle disruption) or in ascidians (by clamping maturation promoting factor levels high) then Ca 2+ oscillations continue indefinitely. Here, we explore the nature of the sperm Ca 2+-releasing factor and examine the relationship between cell cycle resumption and the control of Ca 2+ oscillations at fertilisation.
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Dates et versions

hal-03025745 , version 1 (16-12-2020)

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Victoria L Nixon, Alex Mcdougall, Keith T Jones. Ca2+ oscillations and the cell cycle at fertilisation of mammalian and ascidian eggs. Biology of the Cell, 2000, 92 (3-4), pp.187-196. ⟨10.1016/s0248-4900(00)01068-6⟩. ⟨hal-03025745⟩
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