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Pré-Publication, Document De Travail Année : 2020

SpacePHARER: Sensitive identification of phages from CRISPR spacers in prokaryotic hosts

Résumé

SpacePHARER (CRISPR Spacer Phage-Host Pair Finder) is a sensitive and fast tool for de novo prediction of phage-host relationships via identifying phage genomes that match CRISPR spacers in genomic or metagenomic data. SpacePHARER gains sensitivity by comparing spacers and phages at the protein-level, optimizing its scores for matching very short sequences, and combining evidences from multiple matches, while controlling for false positives. We demonstrate SpacePHARER by searching a comprehensive spacer list against all complete phage genomes.

Dates et versions

hal-03025558 , version 1 (26-11-2020)

Identifiants

Citer

Ruoshi Zhang, Milot Mirdita, Eli Levy Karin, Clovis Norroy, Clovis Galiez, et al.. SpacePHARER: Sensitive identification of phages from CRISPR spacers in prokaryotic hosts. 2020. ⟨hal-03025558⟩
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