Gd(DOTA)-grafted submicronic polysaccharide-based particles functionalized with fucoidan as potential MR contrast agent able to target human activated platelets. - Archive ouverte HAL Access content directly
Journal Articles Carbohydrate Polymers Year : 2020

Gd(DOTA)-grafted submicronic polysaccharide-based particles functionalized with fucoidan as potential MR contrast agent able to target human activated platelets.

Laura Marcela Forero Ramirez
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Elise Gobin
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Rachida Aid-Launais
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Clément Journe
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Fernanda Moraes
  • Function : Author
Luc Picton
Didier Le Cerf
  • Function : Author
Cédric Chauvierre
  • Function : Author
Frédéric Chaubet

Abstract

Early detection of thrombotic events remains a big medical challenge. Dextran-based submicronic particles bearing Gd(DOTA) groups and functionalized with fucoidan have been produced via a simple and green water-in-oil emulsification/co-crosslinking process. Their capacity to bind to human activated platelets was evidenced in vitro as well as their cytocompatibility with human endothelial cells. The presence of Gd(DOTA) moieties was confirmed by elemental analysis and total reflection X-ray fluorescence (TRXF) spectrometry. Detailed characterization of particles was performed in terms of size distribution, morphology, and relaxation rates. In particular, longitudinal and transversal proton relaxivities were respectively 1.7 and 5.0 times higher than those of DOTAREM. This study highlights their potential as an MRI diagnostic platform for atherothrombosis.
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Dates and versions

hal-03022476 , version 1 (22-08-2022)

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Attribution - NonCommercial

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Laura Marcela Forero Ramirez, Elise Gobin, Rachida Aid-Launais, Clément Journe, Fernanda Moraes, et al.. Gd(DOTA)-grafted submicronic polysaccharide-based particles functionalized with fucoidan as potential MR contrast agent able to target human activated platelets.. Carbohydrate Polymers, 2020, 245, pp.116457. ⟨10.1016/j.carbpol.2020.116457⟩. ⟨hal-03022476⟩
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