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Article Dans Une Revue Current Trends in Immunology Année : 2020

Zebrafish Models to Study Inflammasome-Mediated Regulation of Hematopoiesis

Lola Rodríguez-Ruiz
  • Fonction : Auteur
Juan Lozano-Gil
  • Fonction : Auteur
Pablo Mesa-Del-Castillo
  • Fonction : Auteur
María Cayuela
  • Fonction : Auteur
Diana García-Moreno
  • Fonction : Auteur
Ana Pérez-Oliva
  • Fonction : Auteur
Victoriano Mulero

Résumé

Hematopoiesis is a complex process through which immature bone marrow precursor cells mature into all types of blood cells. Although the association of hematopoietic lineage bias (including anemia and neutrophilia) with chronic inflammatory diseases has long been appreciated, the causes involved are obscure. Recently, cytosolic multiprotein inflammasome complexes were shown to activate inflammatory and immune responses, and directly regulate hematopoiesis in zebrafish models; this was deemed to occur via cleavage and inactivation of the master erythroid transcription factor GATA1. Herein summarized are the zebrafish models that are currently available to study this unappreciated role of inflammasome-mediated regulation of hematopoiesis. Novel putative therapeutic strategies, for the treatment of hematopoietic alterations associated with chronic inflammatory diseases in humans, are also proposed.
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Dates et versions

hal-03020978 , version 1 (24-11-2020)

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Lola Rodríguez-Ruiz, Juan Lozano-Gil, Christophe Lachaud, Pablo Mesa-Del-Castillo, María Cayuela, et al.. Zebrafish Models to Study Inflammasome-Mediated Regulation of Hematopoiesis. Current Trends in Immunology, 2020, ⟨10.1016/j.it.2020.10.006⟩. ⟨hal-03020978⟩

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