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Article Dans Une Revue ACS Biomaterials Science and Engineering Année : 2019

Nitric oxide gas delivery by fluorinated poly(ethylene glycol)@graphene oxide carrier towards pharmacotherapeutics

Yitayal Admassu Workie
  • Fonction : Auteur
S Sabrina
  • Fonction : Auteur
Toyoko Imae
  • Fonction : Auteur
  • PersonId : 1082267
Marie Pierre Krafft

Résumé

In view of preparing effective nitric oxide gas carriers, a fluorinated poly(ethylene glycol) (F-PEG) was non-covalently conjugated with acid-treated graphene oxide (GO) to prepare the composite of F-PEG@GO. When the persistence of NO gas doped on GO and F-PEG@GO was investigated for 3 h, the conserved NO gas decreased from 49.00±7.06 to 2.17±1.36 nmol/mg carrier and from 58.51± 6.02 to 4.58±2.22 nmol/mg carrier, respectively. The adsorption of F-PEG on GO and the doping of NO on GO and F-PEG@GO were declarative by the increase of distance between GO sheets, and the NO-doping was also clarified by infrared absorption and X-ray photoelectron spectroscopies. The anti-bacterial effect was higher for NO-conserved F-PEG@GO than for NO-conserved GO and more effective against Staphylococcus aureus than against Escherichia coli. It is evident that the coating of F-PEG on GO is preferable for advancing the loading efficiency, the stability and the biomedical efficacy of NO gas.
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hal-03018428 , version 1 (22-11-2020)

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Yitayal Admassu Workie, S Sabrina, Toyoko Imae, Marie Pierre Krafft. Nitric oxide gas delivery by fluorinated poly(ethylene glycol)@graphene oxide carrier towards pharmacotherapeutics. ACS Biomaterials Science and Engineering, 2019, ⟨10.1021/acsbiomaterials.9b00474⟩. ⟨hal-03018428⟩
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