Click Variations on the Synthesis of 2-Nitrophenyl-4-aryl-1,2,3-triazoles without Isolation of 2-Nitrophenyl Azides - Archive ouverte HAL
Article Dans Une Revue SYNLETT Année : 2020

Click Variations on the Synthesis of 2-Nitrophenyl-4-aryl-1,2,3-triazoles without Isolation of 2-Nitrophenyl Azides

Résumé

We report a series of efficient procedures to prepare 2-nitrophenyl-4-aryl-1,2,3-triazoles avoiding the isolation of potentially hazardous 2-nitrophenyl azides. An organocatalyzed azide-enolate variant allows efficient access to the target compounds while it was shown that a metal-catalyzed azide-alkyne procedure involving a preliminary ­Sonogashira coupling was feasible starting from electron-deficient aryl iodides.

Domaines

Chimie
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Dates et versions

hal-03016919 , version 1 (20-11-2020)

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Citer

Amélie Roux, Federico Cisnetti. Click Variations on the Synthesis of 2-Nitrophenyl-4-aryl-1,2,3-triazoles without Isolation of 2-Nitrophenyl Azides. SYNLETT, 2020, 31 (06), pp.610-614. ⟨10.1055/s-0039-1691524⟩. ⟨hal-03016919⟩
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