Access to Optically-Pure Benzosultams by Superelectrophilic Activation
Résumé
Through superacid activation, N-(arenesulfonyl)-aminoalcohols derived from readily-available ephedrines or amino acids undergo an intramolecular Friedel-Crafts reaction to afford enantiopure benzosultams bearing two adjacent stereocenters in high yields with a fully-controlled diastereoselectivity. Low-temperature NMR spectroscopy demonstrated the crucial role played by the conformationally-restricted chiral dicationic intermediates.
Domaines
Chimie
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Access to Optically-Pure Benzosultams by Superelectrophilic Activation 29052020 without highlight changes.pdf (1.13 Mo)
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