A Meta-Analysis of Semantic Memory in Mild Cognitive Impairment
Résumé
Introduction: Accumulating evidence over the past decade suggests that semantic deficits represent a consistent feature of Mild Cognitive Impairment (MCI). A meta-analysis was performed to examine if semantic deficits are consistently found in patients with MCI. Methods: Studies meeting all inclusion criteria were selected for the current meta-analysis. An effect size and a weight were calculated for each study. A random effect model was performed to assess the overall difference in semantic performances between MCI patients and healthy subjects. Results: 22 studies (476 healthy participants, 476 MCI patients, mean MMSE of the MCI patients: 27.05 ± 0.58) were included in the meta-analysis. Results indicate that MCI patients systematically performed significantly worse than healthy matched controls in terms of overall semantic performance (mean effect size of 1.02; 95% CI [0.80; 1.24]). Discussion: Semantic deficits are a key feature of MCI. Semantic tests should be incorporated in routine clinical assessments.
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