This paper introduces a new combination of software and hardware PIM (Process-in-Memory) architecture to accelerate the variant calling genomic process. PIM translates into bringing data intensive calculations directly where the data is: within the DRAM, enhanced with thousands of processing units. The energy consumption, in large part due to data movement, is significantly lowered at a marginal additional hardware cost. Such design allows an unprecedented level of parallelism to process billions of short reads. Experiments on real PIM devices developed by the UPMEM company show significant speed-up compared to pure software implementation. The PIM solution also compared nicely to FPGA or GPU based acceleration bringing similar to twice the processing speed but most importantly being 5 to 8 times cheaper to deploy with up to 6 times less power consumption.