Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Epilepsia Année : 2015

Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors.

Ine Buffel
  • Fonction : Auteur
Alfred Meurs
  • Fonction : Auteur
Jeanelle Portelli
  • Fonction : Auteur
Robrecht Raedt
  • Fonction : Auteur
Veerle de Herdt
  • Fonction : Auteur
Lynn Sioncke
  • Fonction : Auteur
Wytse Wadman
  • Fonction : Auteur
Frederic Bihel
Martine Schmitt
Kristl Vonck
  • Fonction : Auteur
Frederic Simonin
  • Fonction : Auteur
  • PersonId : 1080003
Ilse Smolders
  • Fonction : Auteur
Paul Boon
  • Fonction : Auteur

Résumé

Drugs with a novel mechanism of action are needed to reduce the number of people with epilepsy that are refractory to treatment. Increasing attention is paid to neuropeptide systems and several anticonvulsant neuropeptides have already been described, such as galanin, ghrelin, and neuropeptide Y (NPY). Many others, however, have not been investigated for their ability to affect epileptic seizures. In this study, the potential anticonvulsant activities of three members of the RF-amide neuropeptide family, neuropeptide FF (NPFF), prolactin-releasing peptide (PrRP), and kisspeptin (Kp) and other receptor ligands (NPFF1/2 R, GPR10, and GRP54, respectively) were tested in the motor cortex stimulation model.

Domaines

Neurobiologie

Dates et versions

hal-03005167 , version 1 (07-01-2021)

Identifiants

Citer

Ine Buffel, Alfred Meurs, Jeanelle Portelli, Robrecht Raedt, Veerle de Herdt, et al.. Neuropeptide FF and prolactin-releasing peptide decrease cortical excitability through activation of NPFF receptors.. Epilepsia, 2015, 56 (3), pp.489-498. ⟨10.1111/epi.12928⟩. ⟨hal-03005167⟩
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