Preparation and physicochemical stability of 50 mg/mL hydroxychloroquine oral suspension in SyrSpend(Ⓡ) SF PH4 (dry) - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue International Journal of Antimicrobial Agents Année : 2020

Preparation and physicochemical stability of 50 mg/mL hydroxychloroquine oral suspension in SyrSpend(Ⓡ) SF PH4 (dry)

Résumé

In the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, hydroxychloroquine has been proposed as a potential agent to treat patients with COVID-19 (coronavirus disease 2019) caused by SARS-CoV-2 infection. Older adults are more susceptible to COVID-19 and some patients may require admission to the intensive care unit, where oral drug administration of solid forms may be compromised in many COVID-19 patients. However, a liquid formulation of hydroxychloroquine is not commercially available. This study describes how to prepare a 50 mg/mL hydroxychloroquine oral suspension using hydroxychloroquine sulfate powder and SyrSpend(Ⓡ) SF PH4 (dry) suspending vehicle. Moreover, a fully validated stability-indicating method has been developed to demonstrate the physicochemical stability of the compounded hydroxychloroquine oral suspension over 60 days under refrigeration (5 ± 3 °C). Finally, use of the proposed oral suspension provides a reliable solution to perform safe and accurate administration of hydroxychloroquine to patients with SARS-CoV-2 infection.
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Dates et versions

hal-03003546 , version 1 (19-11-2020)

Identifiants

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Guillaume Binson, Nicolas Venisse, Alexis Sauvaget, Astrid Bacle, Pauline Lazaro, et al.. Preparation and physicochemical stability of 50 mg/mL hydroxychloroquine oral suspension in SyrSpend(Ⓡ) SF PH4 (dry). International Journal of Antimicrobial Agents, 2020, 56 (6), pp.106201. ⟨10.1016/j.ijantimicag.2020.106201⟩. ⟨hal-03003546⟩
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