New biological indicators to evaluate and monitor radiation-induced damage: An accident case report
Résumé
The aim of this work was to use several new biological indicators to evaluate damage to the main physiological systems in a victim exposed accidentally to ionizing radiation. Blood samples were used for biological dosimetry and for measurement of the plasma concentrations of several molecules: Flt3 ligand to assess the hematopoietic system, citrulline as an indicator of the digestive tract, and several oxysterols as lipid metabolism and vascular markers. The cytogenetic evaluation estimated the dose to the victim to be between 4.2 and 4.8 Gy, depending on the methodology used. Monitoring the Flt3 ligand demonstrated the severity of bone marrow aplasia. In contrast, the citrulline concentration showed the absence of gastrointestinal damage. Variations in oxysterol concentrations suggested radiation-induced damage to the liver and the cardiovascular system. These results were correlated with those from classic biochemical markers, which demonstrated severe damage to the hematopoietic system and suggested the appearance of subclinical damage to the liver and cardiovascular system. These results demonstrate for the first time the importance of a multiparameter biological approach in the evaluation of radiation damage after accidental irradiation. © 2008 by Radiation Research Society.
Mots clés
citrulline
Flt3 ligand
oxysterol
adult
article
blood sampling
bone marrow aplasia
cardiovascular disease
case report
cytogenetics
digestive system injury
dosimetry
heart disease
hematopoietic cell
human
lipid metabolism
liver injury
male
nausea
pathophysiology
priority journal
radiation accident
radiation exposure
radiation injury
radiation sickness
thrombocytopenia
vomiting
Accidents
Radiation
Biological Markers
Blood Cell Count
Cardiovascular System
Cell Movement
Citrulline
Diagnosis
Follow-Up Studies
Gastrointestinal Tract
Hematopoiesis
Humans
Lymphocytes
Radiometry