Accessing 1,8‐Naphthyridones by Metal‐Free Regioselective Amination of Pyridine N ‐oxides/Acid‐Mediated Cyclization
Résumé
A concise and practical method for the metal-free synthesis of 1,8-naphthyridones is described using a two-step approach involving regioselective amination of pyridine N-oxides and acid-mediated cyclization. This is the first synthesis of 1,8-naphthyridones utilizing easily accessible pyridine N-oxides as substrates. Compared to previous reports, this method benefits from simple operation, easy access to starting materials, and a wide substrate scope, providing a variety of novel 1,8-naphthyridones.
Domaines
Chimie
Origine : Fichiers produits par l'(les) auteur(s)
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