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Article Dans Une Revue PLoS ONE Année : 2013

Repression of Osteoblast Maturation by ERRa Accounts for Bone Loss Induced by Estrogen Deficiency

Marlène Gallet
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Soraya Saïdi
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Eric Haÿ
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Johann Photsavang
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Caroline Marty
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Juliette Sailland
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Julie Carnesecchi
Violaine Tribollet
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Bruno Barenton
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Marie-Christine Birling
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Tania Sorg
Olivier Chassande
Martine Cohen-Solal
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Jean-Marc Vanacker
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Résumé

ERRa is an orphan member of the nuclear receptor family, the complete inactivation of which confers resistance to bone loss induced by ageing and estrogen withdrawal to female mice in correlation with increased bone formation in vivo. Furthermore ERRa negatively regulates the commitment of mesenchymal cells to the osteoblast lineage ex vivo as well as later steps of osteoblast maturation. We searched to determine whether the activities of ERRa on osteoblast maturation are responsible for one or both types of in vivo induced bone loss. To this end we have generated conditional knock out mice in which the receptor is normally present during early osteoblast differentiation but inactivated upon osteoblast maturation. Bone ageing in these animals was similar to that observed for control animals. In contrast conditional ERRaKO mice were completely resistant to bone loss induced by ovariectomy. We conclude that the late (maturation), but not early (commitment), negative effects of ERRa on the osteoblast lineage contribute to the reduced bone mineral density observed upon estrogen deficiency. Citation: Gallet M, Saïdi S, Haÿ E, Photsavang J, Marty C, et al. (2013) Repression of Osteoblast Maturation by ERRa Accounts for Bone Loss Induced by Estrogen Deficiency. PLoS ONE 8(1): e54837.
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Dates et versions

hal-02996751 , version 1 (09-11-2020)

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  • HAL Id : hal-02996751 , version 1

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Marlène Gallet, Soraya Saïdi, Eric Haÿ, Johann Photsavang, Caroline Marty, et al.. Repression of Osteoblast Maturation by ERRa Accounts for Bone Loss Induced by Estrogen Deficiency. PLoS ONE, 2013. ⟨hal-02996751⟩
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