Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting - Archive ouverte HAL Access content directly
Journal Articles Journal of Drug Delivery Year : 2013

Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting

Federico Perche
Vladimir P Torchilin
  • Function : Author

Abstract

Liposomes are delivery systems that have been used to formulate a vast variety of therapeutic and imaging agents for the past several decades. They have significant advantages over their free forms in terms of pharmacokinetics, sensitivity for cancer diagnosis and therapeutic efficacy. The multifactorial nature of cancer and the complex physiology of the tumor microenvironment require the development of multifunctional nanocarriers. Multifunctional liposomal nanocarriers should combine long blood circulation to improve pharmacokinetics of the loaded agent and selective distribution to the tumor lesion relative to healthy tissues, remote-controlled or tumor stimuli-sensitive extravasation from blood at the tumor's vicinity, internalization motifs to move from tumor bounds and/or tumor intercellular space to the cytoplasm of cancer cells for effective tumor cell killing. This review will focus on current strategies used for cancer detection and therapy using liposomes with special attention to combination therapies.
Fichier principal
Vignette du fichier
JODD 2013.pdf (1.87 Mo) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

hal-02995820 , version 1 (09-11-2020)

Identifiers

Cite

Federico Perche, Vladimir P Torchilin. Recent Trends in Multifunctional Liposomal Nanocarriers for Enhanced Tumor Targeting. Journal of Drug Delivery, 2013, 2013, pp.1 - 32. ⟨10.1155/2013/705265⟩. ⟨hal-02995820⟩
7 View
47 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More