Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
Jan Schuemann
(1)
,
Alexander Bagley
(2)
,
Ross Berbeco
(3, 4)
,
Kyle Bromma
(5)
,
Karl Butterworth
(6)
,
Hilary Byrne
(7)
,
B Devika Chithrani
(5)
,
Sang Hyun Cho
(2)
,
Jason Cook
(8)
,
Vincent Favaudon
(9)
,
Yaser Gholami
(7)
,
Elisabetta Gargioni
(10)
,
James Hainfeld
(11)
,
Félicien Hespeels
(12)
,
Anne-Catherine Heuskin
(12)
,
Udoka Ibeh
(3, 4)
,
Zdenka Kuncic
(7)
,
Sijumon Kunjachan
(3, 4)
,
Sandrine Lacombe
(13)
,
Stéphane Lucas
(12)
,
François Lux
(14, 15)
,
Stephen Mcmahon
(6)
,
Dmitry Nevozhay
(2, 16)
,
Wilfred Ngwa
(3, 4)
,
J Donald Payne
(17)
,
Sébastien Penninckx
(12)
,
Erika Porcel
(13)
,
Kevin Prise
(6)
,
Hans Rabus
(18)
,
Sharif Ridwan
(19)
,
Benedikt Rudek
(1, 20)
,
Léon Sanche
(21)
,
Bijay Singh
(22)
,
Henry Smilowitz
(19)
,
Konstantin Sokolov
(2, 23, 24)
,
Srinivas Sridhar
(22)
,
Yaroslav Stanishevskiy
(11)
,
Wonmo Sung
(1)
,
Olivier Tillement
(14, 15)
,
Needa Virani
(3, 4)
,
Wassana Yantasee
(25)
,
Sunil Krishnan
(26)
1
Department of Radiation Oncology [Boston]
2 The University of Texas M.D. Anderson Cancer Center [Houston]
3 BWH - Brigham & Women’s Hospital [Boston]
4 Dana-Farber Cancer Institute [Boston]
5 Department of Physics and Astronomy [Victoria]
6 Centre for Cancer Research and Cell Biology
7 School of Physics [Sydney]
8 NanoHybrids, Inc. [Austin]
9 Signalisation, radiobiologie et cancer
10 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
11 Nanoprobes, Inc
12 NARILIS - Namur Research Institute for Life Sciences
13 ISMO - Institut des Sciences Moléculaires d'Orsay
14 NH TherAguix SA [Meylan]
15 iLM - FENNEC - iLM - Formation, élaboration de nanomatériaux et cristaux
16 FEFU - Far Eastern Federal University
17 Aurorad, Inc [Houston]
18 PTB - Physikalisch-Technische Bundesanstalt [Berlin]
19 University of Connecticut Health Center [Farmington]
20 BU - Boston University [Boston]
21 UdeS - Université de Sherbrooke
22 Northeastern University [Boston]
23 Rice University [Houston]
24 Department of Biomedical Engineering, The University of Texas at Austin
25 OHSU - Oregon Health and Science University [Portland]
26 Mayo Clinic [Jacksonville]
2 The University of Texas M.D. Anderson Cancer Center [Houston]
3 BWH - Brigham & Women’s Hospital [Boston]
4 Dana-Farber Cancer Institute [Boston]
5 Department of Physics and Astronomy [Victoria]
6 Centre for Cancer Research and Cell Biology
7 School of Physics [Sydney]
8 NanoHybrids, Inc. [Austin]
9 Signalisation, radiobiologie et cancer
10 UKE - Universitaetsklinikum Hamburg-Eppendorf = University Medical Center Hamburg-Eppendorf [Hamburg]
11 Nanoprobes, Inc
12 NARILIS - Namur Research Institute for Life Sciences
13 ISMO - Institut des Sciences Moléculaires d'Orsay
14 NH TherAguix SA [Meylan]
15 iLM - FENNEC - iLM - Formation, élaboration de nanomatériaux et cristaux
16 FEFU - Far Eastern Federal University
17 Aurorad, Inc [Houston]
18 PTB - Physikalisch-Technische Bundesanstalt [Berlin]
19 University of Connecticut Health Center [Farmington]
20 BU - Boston University [Boston]
21 UdeS - Université de Sherbrooke
22 Northeastern University [Boston]
23 Rice University [Houston]
24 Department of Biomedical Engineering, The University of Texas at Austin
25 OHSU - Oregon Health and Science University [Portland]
26 Mayo Clinic [Jacksonville]
Jan Schuemann
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1081057
Connectez-vous pour contacter l'auteur
Sandrine Lacombe
- Fonction : Auteur
- PersonId : 772110
- ORCID : 0000-0003-3334-9201
Stephen Mcmahon
- Fonction : Auteur
- PersonId : 772113
- ORCID : 0000-0001-5980-6728
Erika Porcel
- Fonction : Auteur
- PersonId : 772109
- ORCID : 0000-0001-8048-4276
Olivier Tillement
- Fonction : Auteur
- PersonId : 938819
- ORCID : 0000-0001-7166-6537
- IdRef : 085752002
Résumé
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z = 22, to Bismuth, Z = 83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.
Fichier principal
Schuemann_et_al_2020_Phys._Med._Biol._10.1088_1361_6560_ab9159.pdf (12.8 Mo)
Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)