Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy - Archive ouverte HAL Access content directly
Journal Articles Chemical Communications Year : 2020

Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy

Abstract

Novel nucleoside derivatives were developed using the strategy of “terminal N,N-dimethylation” to impart tertiary amines to a 1,2,4-triazole nucleoside. The obtained lead compounds displayed significantly improved anticancer activity with dual mechanisms of cell death via apoptosis and autophagy, offering a fresh perspective to searching for new anticancer candidates.
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Dates and versions

hal-02992738 , version 1 (18-11-2020)

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Yanhua Zhang, Xi Liu, Yun Lin, Baoping Lian, Wenjun Lan, et al.. Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy. Chemical Communications, 2020, 56 (69), pp.10014-10017. ⟨10.1039/d0cc04660d⟩. ⟨hal-02992738⟩
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