A thalamocortical circuit for updating action-outcome associations - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue eLife Année : 2019

A thalamocortical circuit for updating action-outcome associations

Virginie Fresno
  • Fonction : Auteur
Shauna Parkes
Angé Lique Faugè Re
  • Fonction : Auteur
Etienne Coutureau
  • Fonction : Auteur
  • PersonId : 1081037

Résumé

The ability to flexibly use knowledge is one cardinal feature of goal-directed behaviors. We recently showed that thalamocortical and corticothalamic pathways connecting the medial prefrontal cortex and the mediodorsal thalamus (MD) contribute to adaptive decision-making (Alcaraz et al., 2018). In this study, we examined the impact of disconnecting the MD from its other main cortical target, the orbitofrontal cortex (OFC) in a task assessing outcome devaluation after initial instrumental training and after reversal of action-outcome contingencies. Crossed MD and OFC lesions did not impair instrumental performance. Using the same approach, we found however that disconnecting the OFC from its other main thalamic afferent, the submedius nucleus, produced a specific impairment in adaptive responding following action-outcome reversal. Altogether, this suggests that multiple thalamocortical circuits may act synergistically to achieve behaviorally relevant functions.
Fichier principal
Vignette du fichier
Fresno_eLife2019.pdf (1.98 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02992694 , version 1 (06-11-2020)

Identifiants

  • HAL Id : hal-02992694 , version 1

Citer

Virginie Fresno, Shauna Parkes, Angé Lique Faugè Re, Etienne Coutureau, Mathieu Wolff. A thalamocortical circuit for updating action-outcome associations. eLife, 2019. ⟨hal-02992694⟩

Collections

CNRS
13 Consultations
31 Téléchargements

Partager

Gmail Facebook X LinkedIn More