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Pré-Publication, Document De Travail Année : 2020

Attentional compensation in neurodegenerative diseases: the model of premanifest Huntington's disease mutation carriers

Lorna Le Stanc
Marine Lunven
  • Fonction : Auteur
Maria Giavazzi
  • Fonction : Auteur
Agnes Sliwinski
  • Fonction : Auteur
Pierre Brugieres
  • Fonction : Auteur
Katia Youssov
  • Fonction : Auteur
Anne-Catherine Bachoud-Lévi
  • Fonction : Auteur
  • PersonId : 908436

Résumé

The ability of the brain to actively cope with neuropathological insults is known as neural compensation. It explains the delayed appearance of cognitive symptoms in neurodegenerative diseases. In contrast to the neural signature of compensation, its cognitive counterpart is largely unknown due to the difficulty of identifying cognitive dysfunctions concealed by compensation mechanisms. We combined computational modelling and neuroanatomical analysis to explore cognitive compensation. We used Huntington's disease (HD) as a genetic model of neurodegenerative disease allowing to study compensation in premanifest mutation carriers (preHDs) free from overt cognitive deficits despite incipient brain atrophy. Twenty preHDs, 28 HD patients and 45 controls performed a discrimination task. We investigated the processes underlying cognitive compensation using drift diffusion models. They assume that the discrimination process relies on the accumulation of evidence at a certain rate and terminates when a response threshold is reached. HD patients' performances were lower than controls' and explained by a higher response threshold and a lower accumulation rate compared to controls. PreHDs performed similarly to controls but had a response threshold between those of controls and HD patients. This nascent increase in response threshold predicted the accumulation rate, which was faster than controls. This suggests that the higher accumulation rate conceals the nascent deficit in response threshold corroborating the capacity of the brain to resist neuropathological insults in preHDs. The higher accumulation rate was associated with parietal hypertrophy in mutation carriers, and with higher hippocampal volumes in preHDs suggesting that cognitive compensation may rely on attentional capacities.
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Dates et versions

hal-02992404 , version 1 (19-11-2020)

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Lorna Le Stanc, Marine Lunven, Maria Giavazzi, Agnes Sliwinski, Pierre Brugieres, et al.. Attentional compensation in neurodegenerative diseases: the model of premanifest Huntington's disease mutation carriers. 2020. ⟨hal-02992404⟩
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