Article Dans Une Revue Cell Reports Année : 2020

cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons

Alice Louail
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Antoine Chaffiol
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Sarah Baudet
Sandrine Couvet
Xavier Nicol
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Résumé

Axonal arbors in many neuronal networks are exuberant early during development and become refined byactivity-dependent competitive mechanisms. Theoretical work proposed non-competitive interactionsbetween co-active axons to co-stabilize their connections, but the demonstration of such interactions islacking. Here, we provide experimental evidence that reducing cyclic AMP (cAMP) signaling in a subset ofretinal ganglion cells favors the elimination of thalamic projections from neighboring neurons, pointing to acAMP-dependent interaction that promotes axon stabilization

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hal-02992307 , version 1 (09-11-2020)

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Alice Louail, Martijn Sierksma, Antoine Chaffiol, Sarah Baudet, Ahlem Assali, et al.. cAMP-Dependent Co-stabilization of Axonal Arbors from Adjacent Developing Neurons. Cell Reports, 2020, 33 (1), pp.108220. ⟨10.1016/j.celrep.2020.108220⟩. ⟨hal-02992307⟩
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