Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Scientific Reports Année : 2020

Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia

Pierre Pouget
  • Fonction : Auteur
  • PersonId : 942190

Résumé

Abstract Myoclonus-dystonia (MD) is a syndrome characterized by myoclonus of subcortical origin and dystonia, frequently associated with psychiatric comorbidities. The motor and psychiatric phenotypes of this syndrome likely result from cortico-striato-thamalo-cerebellar-cortical pathway dysfunction. We hypothesized that reactive and proactive inhibitory control may be altered in these patients. Using the Stop Signal Task, we assessed reactive and proactive inhibitory control in MD patients with (n = 12) and without (n = 21) deep brain stimulation of the globus pallidus interna and compared their performance to matched healthy controls (n = 24). Reactive inhibition was considered as the ability to stop an already initiated action and measured using the stop signal reaction time. Proactive inhibition was assessed through the influence of several consecutive GO or STOP trials on decreased response time or inhibitory process facilitation. The proactive inhibition was solely impaired in unoperated MD patients. Patients with deep brain stimulation showed impairment in reactive inhibition, independent of presence of obsessive–compulsive disorders. This impairment in reactive inhibitory control correlated with intrinsic severity of myoclonus (i.e. pre-operative score). The results point to a dissociation in reactive and proactive inhibitory control in MD patients with and without deep brain stimulation of the globus pallidus interna.
Fichier principal
Vignette du fichier
s41598-020-70926-x.pdf (1.03 Mo) Télécharger le fichier
Origine : Publication financée par une institution

Dates et versions

hal-02992230 , version 1 (01-12-2022)

Identifiants

Citer

Cyril Atkinson-Clement, Clément Tarrano, Camille-Albane Porte, Nicolas Wattiez, Cecile Delorme, et al.. Dissociation in reactive and proactive inhibitory control in Myoclonus dystonia. Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-70926-x⟩. ⟨hal-02992230⟩
103 Consultations
47 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More