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Article Dans Une Revue Nucleosides, Nucleotides and Nucleic Acids Année : 2020

Efficient one-pot, three-component procedure to prepare new α-aminophosphonate and phosphonic acid acyclic nucleosides

Laila Baddi
  • Fonction : Auteur
Driss Ouzebla
  • Fonction : Auteur
Az-Eddine El Mansouri
  • Fonction : Auteur
Michael Smietana
Hassan Lazrek
  • Fonction : Auteur

Résumé

An efficient one-pot three-component Kabachnik-Fields reaction of aldehydes (acyclic nucleosides), amines (or amino acid), and triethyl phosphite proceeded for the synthesis of aminophosphonates using natural phosphate coated with iodine (I-2@NP) as a catalyst. The novel alpha-aminophosphonate and phosphonic acid acyclic nucleosides were tested for their anti-HCV and anti-HIV activities. The molecular docking showed that the non-activity of these compounds could be due to the absence of hydrophobic pharmacophores.
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Dates et versions

hal-02989697 , version 1 (06-11-2020)

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Citer

Laila Baddi, Driss Ouzebla, Az-Eddine El Mansouri, Michael Smietana, Jean-Jacques Vasseur, et al.. Efficient one-pot, three-component procedure to prepare new α-aminophosphonate and phosphonic acid acyclic nucleosides. Nucleosides, Nucleotides and Nucleic Acids, In press, pp.1-25. ⟨10.1080/15257770.2020.1826516⟩. ⟨hal-02989697⟩
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