Functional versatility of the CDK inhibitor p57Kip2 - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Cell and Developmental Biology Année : 2020

Functional versatility of the CDK inhibitor p57Kip2

Résumé

The cyclin/CDK inhibitor p57 Kip2 belongs to the Cip/Kip family, with p21 Cip1 and p27 Kip1 , and is the least studied member of the family. Unlike the other family members, p57 Kip2 has a unique role during embryogenesis and is the only CDK inhibitor required for embryonic development. p57 Kip2 is encoded by the imprinted gene CDKN1C, which is the gene most frequently silenced or mutated in the genetic disorder Beckwith-Wiedemann syndrome (BWS), characterized by multiple developmental anomalies. Although initially identified as a cell cycle inhibitor based on its homology to other Cip/Kip family proteins, multiple novel functions have been ascribed to p57 Kip2 in recent years that participate in the control of various cellular processes, including apoptosis, migration and transcription. Here, we will review our current knowledge on p57 Kip2 structure, regulation, and its diverse functions during development and homeostasis, as well as its potential implication in the development of various pathologies, including cancer.
Fichier principal
Vignette du fichier
2020-Creff and Besson Front Cell Dev Biol 2020.pdf (1.69 Mo) Télécharger le fichier
Origine Publication financée par une institution

Dates et versions

hal-02989021 , version 1 (24-11-2020)

Identifiants

Citer

Justine Creff, Arnaud Besson. Functional versatility of the CDK inhibitor p57Kip2. Frontiers in Cell and Developmental Biology, 2020, ⟨10.3389/fcell.2020.584590⟩. ⟨hal-02989021⟩

Collections

CNRS
14 Consultations
24 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More