Study of the influence of radionuclide biokinetics on the efficiency of in vivo counting using Monte Carlo simulation
Résumé
To improve calibration methods of in vivo counting, our laboratory has developed a computer tool to model internal contamination and assess in vivo activity and corresponding organ absorbed doses. The aim of the recent work was to define a more realistic source based on biokinetic models. The influence of the biokinetic parameters on the in vivo counting was studied through the simulation of an acute inhalation intake of Am. The tissue distribution of activity predicted by the biokinetic model was visualized. Two equivalent methods for determination of the efficiency related to the total activity distributed in the body were used. The comparison between the efficiency taking the biokinetics into account and the classically estimated efficiency quantifies the influence of the activity distribution in the body and provides conversion factors for correcting the classical efficiency to account for biokinetics. ©2009Health Physics Society.
Mots clés
americium 241
radioisotope
article
body distribution
in vivo study
kinetics
Monte Carlo method
prediction
priority journal
radiation measurement
tissue distribution
algorithm
antibody specificity
bioassay
biological model
computer simulation
human
methodology
radiation dose
relative biologic effectiveness
sensitivity and specificity
whole body counting
Algorithms
Biological Assay
Computer Simulation
Humans
Kinetics
Models
Biological
Monte Carlo Method
Organ Specificity
Radiation Dosage
Radioisotopes
Relative Biological Effectiveness
Sensitivity and Specificity
Tissue Distribution
Whole-Body Counting