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Article Dans Une Revue Current Opinion in Structural Biology Année : 2020

ATPases: how an old dog learnt new tricks - structure and mechanism of lipid flippases

Joseph A. Lyons
  • Fonction : Auteur
Milena Timcenko
  • Fonction : Auteur
Thibaud Dieudonne
  • Fonction : Auteur
Poul Nissen

Résumé

Type 4 P-type ATPases (P4-ATPases) are lipid flippases that drive the active, inward directed translocation (flip) of lipids in eukaryotic membranes. The resulting lipid asymmetry potentiates the membrane and is essential for a wide range of cellular processes such as vesicle biogenesis and trafficking and membrane protein regulation, whereas dissipation of lipid asymmetry is required in blood coagulation and apoptosis. Through recent advances in cryo-electron microscopy, several landmark structures of yeast and human lipid flippases have been reported, highlighting the similarities and differences they share with the cation transporting P-type ATPases. Here, we discuss the recent lipid flippase structures in the context of subunit architecture and organization, auto-regulation and lipid transport.
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Dates et versions

hal-02968379 , version 1 (15-10-2020)

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Joseph A. Lyons, Milena Timcenko, Thibaud Dieudonne, Guillaume Lenoir, Poul Nissen. ATPases: how an old dog learnt new tricks - structure and mechanism of lipid flippases. Current Opinion in Structural Biology, 2020, 63, pp.65--73. ⟨10.1016/j.sbi.2020.04.001⟩. ⟨hal-02968379⟩
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