Review of retrospective dosimetry techniques for external ionising radiation exposures
M. Brai
(1, 2)
,
E. A. Ainsbury
(3)
,
E. Bakhanova
(4)
,
J. F. Barquinero
,
V. Chumak
(4)
,
V. Correcher
(5)
,
F. Darroudi
(6)
,
P. Fattibene
(7, 8)
,
G. Gruel
(9)
,
I. Guclu
,
S. Horn
(3)
,
A. Jaworska
(10)
,
U. Kulka
(11)
,
C. Lindholm
(12)
,
D. Lloyd
(3)
,
A. Longo
(1, 2)
,
M. Marrale
(1, 2)
,
O. Monteiro Gil
(13)
,
U. Oestreicher
(11)
,
J. Pajic
,
B. Rakic
(3)
,
H. Romm
(11)
,
F. Trompier
(9)
,
I. Veronese
(14)
,
P. Voisin
(9)
,
A. Vral
(15)
,
C. A. Whitehouse
,
A. Wieser
(16)
,
C. Woda
(16)
,
A. Wojcik
(17)
,
K. Rothkamm
(3)
1
Università degli studi di Palermo - University of Palermo
2 INFN - Istituto Nazionale di Fisica Nucleare, Sezione di Catania
3 Centre for Radiation, Chemical and Environmental Hazards
4 National Academy of Medical Sciences of Ukraine
5 CIEMAT - Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
6 LUMC - Leiden University Medical Center
7 ISS - Istituto Superiore di Sanità = National Institute of Health
8 INFN - Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1]
9 IRSN - Institut de Radioprotection et de Sûreté Nucléaire
10 Norwegian Radiation and Nuclear Safety Authority
11 BfS - Bundesamt für Strahlenschutz - Federal Office for Radiation Protection
12 STUK - Säteilyturvakeskus [Suomi] = Radiation and Nuclear Safety Authority in Finland = Autorité de sûreté nucléaire et de radioprotection [Finlande]
13 Instituto Tecnológico e Nuclear
14 UNIMI - Università degli Studi di Milano = University of Milan
15 Department of Basic Medical Sciences [Ghent, Belgium]
16 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
17 Stockholm University
2 INFN - Istituto Nazionale di Fisica Nucleare, Sezione di Catania
3 Centre for Radiation, Chemical and Environmental Hazards
4 National Academy of Medical Sciences of Ukraine
5 CIEMAT - Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas
6 LUMC - Leiden University Medical Center
7 ISS - Istituto Superiore di Sanità = National Institute of Health
8 INFN - Istituto Nazionale di Fisica Nucleare [Sezione di Roma 1]
9 IRSN - Institut de Radioprotection et de Sûreté Nucléaire
10 Norwegian Radiation and Nuclear Safety Authority
11 BfS - Bundesamt für Strahlenschutz - Federal Office for Radiation Protection
12 STUK - Säteilyturvakeskus [Suomi] = Radiation and Nuclear Safety Authority in Finland = Autorité de sûreté nucléaire et de radioprotection [Finlande]
13 Instituto Tecnológico e Nuclear
14 UNIMI - Università degli Studi di Milano = University of Milan
15 Department of Basic Medical Sciences [Ghent, Belgium]
16 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
17 Stockholm University
J. F. Barquinero
- Fonction : Auteur
G. Gruel
- Fonction : Auteur
- PersonId : 1056181
- IdHAL : gaetan-gruel
- ORCID : 0000-0001-7856-818X
I. Guclu
- Fonction : Auteur
J. Pajic
- Fonction : Auteur
C. A. Whitehouse
- Fonction : Auteur
Résumé
The current focus on networking and mutual assistance in the management of radiation accidents or incidents has demonstrated the importance of a joined-up approach in physical and biological dosimetry. To this end, the European Radiation Dosimetry Working Group 10 on 'Retrospective Dosimetry' has been set up by individuals from a wide range of disciplines across Europe. Here, established and emerging dosimetry methods are reviewed, which can be used immediately and retrospectively following external ionising radiation exposure. Endpoints and assays include dicentrics, translocations, premature chromosome condensation, micronuclei, somatic mutations, gene expression, electron paramagnetic resonance, thermoluminescence, optically stimulated luminescence, neutron activation, haematology, protein biomarkers and analytical dose reconstruction. Individual characteristics of these techniques, their limitations and potential for further development are reviewed, and their usefulness in specific exposure scenarios is discussed. Whilst no single technique fulfils the criteria of an ideal dosemeter, an integrated approach using multiple techniques tailored to the exposure scenario can cover most requirements. © The Author 2010. Published by Oxford University Press. All rights reserved.