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Article Dans Une Revue Chemistry - A European Journal Année : 2020

Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials

Résumé

A simple and efficient way to synthesize peptide-containing silicone materials is described. Silicone oils containing a chosen ratio of bioactive peptide sequences were prepared by acid-catalyzed copolymerization of dichlorodimethylsilane, hybrid dichloromethyl peptidosilane, and Si(vinyl)- or SiH-functionalized monomers. Functionalized silicone oils were first obtained and then, after hydrosilylation cross-linking, bioactive polydimethylsiloxane (PDMS)-based materials were straightforwardly obtained. The introduction of an antibacterial peptide yielded PDMS materials showing activity against Staphylococcus aureus. PDMS containing RGD ligands showed improved cell-adhesion properties. This generic method was fully compatible with the stability of peptides and thus opened the way to the synthesis of a wide range of biologically active silicones.

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Matériaux
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Dates et versions

hal-02957956 , version 1 (05-10-2020)

Identifiants

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Julie Martin, Mohammad Wehbi, Cécile Echalier, Sylvie Hunger, Audrey Bethry, et al.. Direct Synthesis of Peptide‐Containing Silicones: A New Way to Bioactive Materials. Chemistry - A European Journal, 2020, 26, pp.12839. ⟨10.1002/chem.202001571⟩. ⟨hal-02957956⟩
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