pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Nanomaterials Année : 2020

pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery

Résumé

Supramolecular constructions of amphiphilic dendritic molecules are promising vehicles for anti-cancer drug delivery due to the flexibility of their architecture, high drug loading capacity and avoiding off-target effects of a drug. Herein, we report a new class of amphiphilic dendritic species-triazine-carbosilane dendrons readily self-assembling into pH-sensitive dendrimersomes. The dendrimersomes efficiently encapsulate anticancer drugs doxorubicin and methotrexate. Chemodrug-loaded dendrimersomes have dose-related cytotoxic activity against leukaemia cell lines 1301 and K562. Our findings suggest that triazine-carbosilane dendrimersomes are prospective drug carriers for anti-cancer therapy.
Fichier principal
Vignette du fichier
nanomaterials-10-01899.pdf (3.07 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02947507 , version 1 (24-09-2020)

Identifiants

Citer

Evgeny Apartsin, Nadezhda Knauer, Valeria Arkhipova, Ekaterina Pashkina, Alina Aktanova, et al.. pH-Sensitive Dendrimersomes of Hybrid Triazine-Carbosilane Dendritic Amphiphiles-Smart Vehicles for Drug Delivery. Nanomaterials, 2020, 10, pp.1899. ⟨10.3390/nano10101899⟩. ⟨hal-02947507⟩
46 Consultations
31 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More