Palladium-Catalyzed C(sp 2 )−H Alkylation of Aldehyde-Derived Hydrazones with Functionalized Difluoromethyl Bromides
Résumé
A palladium-catalyzed C(sp 2) À Hd ifluoromethylation of aldehyde-derived hydrazones using bromodifluorome-thylated compounds to affordt he corresponding functional-ized difluoromethylketone hydrazones has been established. It is proposed that ar adical/SET mechanism proceeding via ad ifluoroalkylr adical mayb ei nvolved in the catalytic cycle. Applications of the methodology to the synthesis of a,a-difluoro-b-ketoesters and a,a-difluoroketones (RCOCF 2 H) have been illustrated.