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Communication Dans Un Congrès Année : 2020

A semantics-guided warping for semi-supervised video object instance segmentation

Résumé

Unlabelled - Medicinally active compounds in the flavonoid class of phytochemicals are being studied for antiviral action against various DNA and RNA viruses. Quercetin is a flavonoid present in a wide range of foods, including fruits and vegetables. It is said to be efficient against a wide range of viruses. This research investigated the usefulness of Quercetin against Hepatitis C virus, Dengue type 2 virus, Ebola virus, and Influenza A using computational models. A molecular docking study using the online tool PockDrug was accomplished to identify the best binding sites between Quercetin and PubChem-based receptors. Network-pharmacological assay to opt to verify function-specific gene-compound interactions using STITCH, STRING, GSEA, Cytoscape plugin cytoHubba. Quercetin explored tremendous binding affinity against NS5A protein for HCV with a docking score of - 6.268 kcal/mol, NS5 for DENV-2 with a docking score of - 5.393 kcal/mol, VP35 protein for EBOV with a docking score of - 4.524 kcal/mol, and NP protein for IAV with a docking score of - 6.954 kcal/mol. In the network-pharmacology study, out of 39 hub genes, 38 genes have been found to interact with Quercetin and the top interconnected nodes in the protein-protein network were (based on the degree of interaction with other nodes) and Negative binding energies were noticed in Quercetin-receptor interaction. Results demonstrate that Quercetin could be a potential antiviral agent against these viral diseases with further study in models. Supplementary information - The online version contains supplementary material available at 10.1007/s40203-022-00132-2.
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Dates et versions

hal-02934290 , version 1 (01-12-2020)

Identifiants

Citer

Q.F. Wang, Lu Zhang, K. Kpalma. A semantics-guided warping for semi-supervised video object instance segmentation. 17th International Conference on Image Analysis and Recognition, ICIAR 2020, Jun 2020, Varzim, Portugal. pp.186-195, ⟨10.1007/978-3-030-50347-5_17⟩. ⟨hal-02934290⟩
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