Population monitoring is a challenge in many areas such as public health or ecology. We propose a method to model and monitor population distributions over space and time, in order to build an alert system for spatio-temporal data evolution. Assuming that mixture models can correctly model populations, we propose new versions of the Expectation-Maximization algorithm to better estimate both the number of clusters together with their parameters. We then combine these algorithms with a temporal statistical model, allowing to detect dynamical changes in population distributions, and name it a spatio-temporal mixture process (STMP). We test STMP on synthetic data, and consider several different behaviors of the distributions, to adjust this process. Finally, we validate STMP on a real data set of positive diagnosed patients to corona virus disease 2019. We show that our pipeline correctly models evolving real data and detects epidemic changes.