Mechanisms of spindle assembly and size control
Résumé
The spindle is crucial for cell division by allowing the faithful segregation of replicated chromosomes to daughter cells. Proper segregation is ensured only if microtubules and hundreds of other associated factors interact to assemble this complex structure with the appropriate architecture and size. In this review, we describe the latest view of spindle organization as well as the molecular gradients and mechanisms underlying microtubule nucleation and spindle assembly. We then discuss the overlapping physical and molecular constraints that dictate spindle morphology, concluding with a focus on spindle size regulation.
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Guilloux et al-2020-Mechanisms of spindle assembly and size control.pdf (1.52 Mo)
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