C35 Hopanoid Side Chain Biosynthesis: Reduction of Ribosylhopane into Bacteriohopanetetrol by a Cell-Free System Derived from Methylobacterium organophilum - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ChemBioChem Année : 2015

C35 Hopanoid Side Chain Biosynthesis: Reduction of Ribosylhopane into Bacteriohopanetetrol by a Cell-Free System Derived from Methylobacterium organophilum

Résumé

The major bacterial triterpenoids of the hopane series each consist of a C30 triterpene hopane moiety and an additional nonterpene C5 side chain derived from d-ribose and linked through its C-5 carbon atom to the hopane side chain. Bacteriohopanetetrol and aminobacteriohopanetriol are the most common representatives of this natural product series, adenosylhopane and ribosylhopane being putative precursors. Deuterium- labelled ribosylhopane was obtained by hemisynthesis and converted into deuterium-labelled bacteriohopanetetrol in the presence of NADPH, thus giving evidence of this as yet unknown precursor-to-product relationship in the bacterial hopanoid metabolic pathway.

Domaines

Chimie organique

Dates et versions

hal-02923290 , version 1 (26-08-2020)

Identifiants

Citer

Anne Bodlenner, Wenjun Liu, Guillaume Hirsch, Philippe Schaeffer, Martin Blumenberg, et al.. C35 Hopanoid Side Chain Biosynthesis: Reduction of Ribosylhopane into Bacteriohopanetetrol by a Cell-Free System Derived from Methylobacterium organophilum. ChemBioChem, 2015, 16 (12), pp.1764-1770. ⟨10.1002/cbic.201500021⟩. ⟨hal-02923290⟩
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