More than smell. COVID-19 is associated with severe impairment of smell, taste, and chemesthesis - Archive ouverte HAL Access content directly
Journal Articles Chemical Senses Year : 2020

More than smell. COVID-19 is associated with severe impairment of smell, taste, and chemesthesis

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Valentina Parma
Christine E. Kelly
  • Function : Author
Alyssa J Bakke
Keiland W Cooper
Cédric Bouysset
Richard C Gerkin
Alexander W Fjaeldstad
Lina Öztürk
  • Function : Author
Luis R Saraiva
Cailu Lin
Sébastien Fiorucci
Jérôme Golebiowski
Eugeni Roura
Juyun Lim
K L Whitcroft
  • Function : Author
Camille Ferdenzi
Aytug Altundag
  • Function : Author
Alberto Macchi
Alexia Nunez-Parra
  • Function : Author
Carl M Philpott
Johan N. Lundström
  • Function : Author
  • PersonId : 947682
Michael Schmuker
  • Function : Author
  • PersonId : 854773
Enrique Santamaria
  • Function : Author
Jonas K Olofsson
Noam Karni
  • Function : Author
Rafieh Alizadeh
Forschungszentrum Jülich
  • Function : Author
Danielle R. Reed
John E. Hayes
  • Function : Author
  • PersonId : 1089157

Abstract

Recent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, and generally lacked quantitative measurements. Here, we report the development, implementation and initial results of a multi-lingual, international questionnaire to assess self-reported quantity and quality of perception in three distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change +/-100) revealed a mean reduction of smell (-79.7 +/- 28.7, mean +/- SD), taste (-69.0 +/- 32.6), and chemesthetic (-37.3 +/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis. The multimodal impact of COVID-19 and lack of perceived nasal obstruction suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.
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Dates and versions

hal-02911030 , version 1 (03-08-2020)

Licence

Attribution - NonCommercial - NoDerivatives - CC BY 4.0

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Valentina Parma, Kathrin Ohla, Maria G Veldhuizen, Masha Niv, Christine E. Kelly, et al.. More than smell. COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chemical Senses, 2020, 45 (7), pp.609-622. ⟨10.1093/chemse/bjaa041⟩. ⟨hal-02911030⟩
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