Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): exploration via a physiologically based toxicokinetic model - Archive ouverte HAL Access content directly
Journal Articles Aquatic Toxicology Year : 2020

Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): exploration via a physiologically based toxicokinetic model

Abstract

Salmonids are poikilotherms which means that their internal temperature varies with that of water. Water temperature thus controls many of their lifecycle processes and physiological functions, which could influence the mechanisms of absorption, distribution, metabolism and excretion (ADME) of many substances, including perfluorinated alkyl substances (PFAAs). However, the processes governing the fate of PFAAs are still poorly understood in fish. Here we developed a physiologically based toxicokinetic (PBTK) model for rainbow trout (Oncorhynchus mykiss) to study changes in physiological functions and PFAA ADME at different temperatures. The model was calibrated using experimental data from dietary exposure to perfluorooctane sulfonate at 7°C and 19°C. Predictions of PFOS concentrations were globally satisfactory at both temperatures, when accounting for the influence of temperature on growth, ventilation rate, cardiac output, clearances, and absorption rates. Accounting for the influence of temperature on tissue-plasma partition coefficients significantly improved predicted in-organ PFOS concentrations.

Domains

Ecotoxicology
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Dates and versions

hal-02910976 , version 1 (03-08-2020)

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Alice Vidal, Marc Babut, Jeanne Garric, Rémy Beaudouin. Temperature effect on perfluorooctane sulfonate toxicokinetics in rainbow trout (Oncorhynchus mykiss): exploration via a physiologically based toxicokinetic model. Aquatic Toxicology, 2020, 225, pp.44. ⟨10.1016/j.aquatox.2020.105545⟩. ⟨hal-02910976⟩
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