Bioprospecting of Nitrogenous Heterocyclic Scaffolds with Potential Action for Neglected Parasitosis: A Review - HAL Accéder directement au contenu
Article dans une revue Current Pharmaceutical Design Année : 2020

Bioprospecting of Nitrogenous Heterocyclic Scaffolds with Potential Action for Neglected Parasitosis: A Review

Résumé

Neglected parasitic diseases are a group of infections currently considered as a worldwide concern. This fact can be attributed to the migration of these diseases to developed and developing countries, associated with therapeutic insufficiency resulted from the low investment in the research and development of new drugs. In order to overcome this situation, bioprospecting supports medicinal chemistry in the identification of new scaffolds with therapeutically appropriate physicochemical and pharmacokinetic properties. Among them, we highlight the nitrogenous heterocyclic compounds, as they are secondary metabolites of many natural products with potential biological activity. The objective of this work was to review studies within a 10-year timeframe (2009-2019), focusing on the pharmacological application of nitrogen bioprospectives (pyrrole, pyridine, indole, quino-line, acridine, and their respective derivatives) against neglected parasitic infections (malaria, leishmania, try-panosomiases, and schistosomiasis), and their application as a template for semi-synthesis or total synthesis of potential antiparasitic agents. In our studies, it was observed that among the selected articles, there was a higher focus on the attempt to identify and obtain novel antimalarial compounds, in a way that an extensive amount of studies involving all heterocyclic nitrogen nuclei were found. On the other hand, the parasites with the lowest number of publications up until the present date have been trypanosomiasis, especially those caused by Trypano-soma cruzi, and schistosomiasis, where some heterocyclics have not even been cited in recent years. Thus, we conclude that despite the great biodiversity on the planet, little attention has been given to certain neglected tropical diseases, especially those that reach countries with a high poverty rate.
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hal-02908646, version 1 (31-07-2020)

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Sonaly Lima Albino, Jamire Muriel da Silva, Michelangela Suelleny de Caldas Nobre, Yvnni Maria Sales de Medeiros E Silva, Mirelly Barbosa Santos, et al.. Bioprospecting of Nitrogenous Heterocyclic Scaffolds with Potential Action for Neglected Parasitosis: A Review. Current Pharmaceutical Design, In press, ⟨10.2174/1381612826666200701160904⟩. ⟨hal-02908646⟩
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