This paper will cover recent developments and trends in ASICs designed by Weeroc and its affiliated laboratory, OMEGA (IN2P3/CNRS/Ecole Polytechnique), for medical imaging and particle physics applications. Two categories of ASIC will be reviewed: ASICs for medical imaging (e.g., TOF-PET) which have been designed for obtaining the lowest CTR (sub 100 ps RMS) and ASICs in particles physics which are driven by readout of fast silicon sensors in the HL-LHC upgrade program.